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DHEAS, testosterone, and several other androgens are used to evaluate adrenal function and to distinguish androgen-secreting conditions that are caused by the adrenal glands from those that originate in the ovaries or testes.
DHEAS can be measured to help diagnose tumors in the cortex of the adrenal gland (adrenocortical tumors), adrenal cancers, and congenital adrenal hyperplasia or adult-onset adrenal hyperplasia and to separate these conditions from ovarian tumors and cancers.
Concentrations of DHEAS are often measured, along with other hormones such as FSH, LH, prolactin, estrogen, and testosterone, to help diagnose polycystic ovarian syndrome (PCOS) and to help rule out other causes of infertility, amenorrhea, and hirsutism.
DHEAS levels may be ordered, along with other hormones, to investigate and diagnose the cause of virilization in young girls and early (precocious) puberty in young boys.